The neuroprotective effects of the ethanolic extract of Syzygium polyanthum in benzene-induced rats

The toxic and carcinogenic effects of benzene are caused by several factors such as the duration, mode level exposure, individual susceptibility (age, gender, lifestyle, pre-existing diseases). Syzygium polyanthum (Wight) Walp, known bay leaf, is a species Myrtaceae family. It used traditional medicine various ethnic groups, especially in Southeast Asia, Malaysia Indonesia. This study aimed to determine neuroprotective effect ethanolic extract using 44 rats. These experimental animals were divided into eleven each consisting 4 normal group was given only CMC (carboxymethyl cellulose), while negative 1 2 100 mg/kg BW every 6 3 days intraperitoneally. Furthermore, positive groups treated with vitamin c + mg/kgbw days, respectively. Group I-6 rats at dose 400, 600, 4800 during 21 experiment. On day 22, injected 1% ketamine their blood samples taken directly from heart. followed Interferon Gamma COX-2. result showed that can reduce biomarker Interferon-gamma COX-2 benzene-induced